Bioprocess monitoring.


The Impact of Waveguide-Enhanced Raman on Bioprocess Monitoring.

The implementation of Process Analytical Technologies (PATs), recommended by regulatory agencies for over 20 years, has revolutionized the bioprocessing industry by significantly improving process efficiency, product quality, and regulatory compliance. Among the various PAT techniques, Raman spectroscopy stands out as a particularly powerful tool. Raman spectroscopy’s in-line and real-time monitoring capabilities have brought about transformative changes in bioprocessing by enabling precise control and optimization of critical parameters throughout the entire production cycle. Its ability to offer detailed chemical information has led to enhanced process understanding, facilitating data-driven decisions and yielding numerous advantages in terms of both operational efficiency and product quality.

In the field of bioprocesses and biotechnology, where precision and efficiency are paramount, our cutting-edge sensor technology revolutionizes the landscape. Our sensors, based on Waveguide Enhanced Raman Spectroscopy (WERS), bring a new era of real-time, non-invasive analysis to bioreactors and flow systems of all scales. Whether you’re operating with single-use technologies or traditional setups, our compact and versatile sensors provide a comprehensive view of your bioprocesses, optimizing yield, minimizing waste, and accelerating development. In the pursuit of sustainable and high-quality bioproduction, our technology is your guiding light.

in your industry.

01. Upstream

Integration into bioreactors and production systems

Accuracy and real-time monitoring are crucial for achieving optimal yields and product quality. Our sensor technology, rooted in Waveguide Enhanced Raman Spectroscopy (WERS), seamlessly integrates into bioreactors and production systems, complementing the way upstream processes are managed. By placing our sensors at the heart of bioreactors, industries gain unprecedented insights into microbial cultures and bio-chemical reactions. This integration enables operators to monitor key parameters such as cell growth, nutrient levels, and metabolic activity in real-time, all without the need for time-consuming and invasive sampling. The result is a higher degree of process control, leading to enhanced productivity, reduced resource consumption, and ultimately, more sustainable bioprocessing operations. With our sensors as your ally, the bioprocess industry is poised to reach new heights of efficiency and product consistency.


  • Enhanced Process Control: Integration of our sensors into bioreactors empowers industries to closely monitor critical parameters, leading to higher yields and improved product quality via targeted efficient and automatized control loops.
  • Reduced Sampling Costs: By eliminating the need for frequent and invasive sampling, our sensors offer a cost-effective alternative. Industries can redirect resources previously spent on sampling and analysis towards process optimization and innovation.
  • Sustainability Advancements: Real-time monitoring in bioreactors allows for more sustainable bioprocessing practices. Reduced resource consumption, minimized waste, and improved efficiency contribute to a greener and more environmentally responsible industry.

02. Downstream

Integration into harvest and purification systems

Precision and efficiency in the downstream stages of production are essential. Our cutting-edge sensor technology, underpinned by Waveguide Enhanced Raman Spectroscopy (WERS), seamlessly integrates into harvest and purification systems, revolutionizing the way downstream processes are managed. By deploying our sensors in these critical stages, industries gain real-time insights into the composition and quality of their bioproducts. This integration enables operators to optimize separation and purification processes with unmatched accuracy, ensuring the highest possible product purity and minimizing resource wastage. With our sensors, industries can reduce the environmental footprint of their operations, enhance product quality, and achieve unparalleled levels of process efficiency, marking a significant leap forward in the evolution of the bioprocess industry.


  • Purity Assurance: Integrating our sensors into harvest and purification systems ensures the highest level of product purity. This opportunity reduces the risk of impurities and contamination, vital for industries operating in stringent regulatory environments such as pharmaceuticals.
  • Resource Optimization: Real-time data from our sensors allows for precise control over downstream processes. This optimization opportunity reduces the use of valuable resources like solvents and energy, ultimately lowering operational costs.
  • Product Consistency: Our sensors provide an opportunity to consistently produce high-quality bioproducts. This is especially critical for industries aiming to meet stringent quality standards and deliver reliable products to the market.

for bioprocessing.

Cost and single use compatibility

By reducing the cost of probes, Raman spectroscopy can be applied as a new solution for single-use technologies. Open to wider cost-efficient options, several probes can be connected to a single control unit.

Optimize yields and product quality

By monitoring both qualitative and quantitative specific data from your process, real time information becomes accessible.

Sensing area

The sensing area of our sensors, where the light interacts with the medium, is only a few (<5) mm². This means that very small volumes are enough to make a measurement.

Sensitivity and selectivity for all molecules

By optimizing the light-sample interaction, we ensure optimal sensitivity and selectivity. As our technology is based on molecular vibrations, we can detect a large panel of information within the same measurement.

Sample preparation and measurement time

No preparation needed, only a few seconds are required to obtain your data.


Material made of USP class VI, all classic industrial sterilisation are covered.
Compatible with all sterilisation methods.

Possible use cases.
Biotechnology based applications

Visual representation of your bioprocess over time

Specific bioproduction represented in a model

Identify processes deviation in real-time